UNC2250

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

UNC2250  纯度: 99.22%

UNC2250 是一种有效选择性的 Mer 抑制剂,IC50为 1.7 nM,比相关的激酶 Axl 和 Tyro3 选择性高 160 倍和 60 倍。

UNC2250

UNC2250 Chemical Structure

CAS No. : 1493694-70-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥798 In-stock
5 mg ¥725 In-stock
10 mg ¥1200 In-stock
50 mg ¥4241 In-stock
100 mg ¥7400 In-stock
200 mg   询价  
500 mg   询价  

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UNC2250 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
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生物活性

UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

IC50 & Target

IC50: 1.7 nM (Mer)[1]

体外研究
(In Vitro)

UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM[1].
UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer[1].
UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines[1] .

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 697 B-ALL cells
Concentration: 5, 10, 20, 50, 100, 250, 500 nM
Incubation Time: 1 hour
Result: Inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM.

分子量

440.58

Formula

C24H36N6O2

CAS 号

1493694-70-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 20 mg/mL (45.39 mM; ultrasonic and warming and heat to 60°C)

0.1 M HCL : 12.5 mg/mL (28.37 mM; ultrasonic and adjust pH to 3 with HCl)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2697 mL 11.3487 mL 22.6974 mL
5 mM 0.4539 mL 2.2697 mL 4.5395 mL
10 mM 0.2270 mL 1.1349 mL 2.2697 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56(23): p. 9683-92.

    [2]. Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.

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