上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
SID 26681509 纯度: 98.26%
SID 26681509 是一种有效的,可逆的,竞争性的,选择性的人组织蛋白酶 L (human cathepsin L) 抑制剂,IC50 为 56 nM。SID 2668150 抑制 Plasmodium falciparum 的体外繁殖,并抑制 Leishmania major,IC50 分别为 15.4 μM 和 12.5 μM。SID 26681509 对组织蛋白酶 G 没有抑制活性。
SID 26681509 Chemical Structure
CAS No. : 958772-66-2
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1950 | In-stock | |
5 mg | ¥5800 | In-stock | |
10 mg | ¥9800 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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SID 26681509 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G[1]. |
IC50 & Target |
IC50: 56 nM (Human cathepsin L), 0.5 μM (Cathepsin V), 15.4 μM (Plasmodium falciparum), 12.5 μM (Leishmania major)[1] |
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体外研究 (In Vitro) |
After a 4 hr preincubation with cathepsin L, SID 26681509 becomes more potent, demonstrating an IC50 of 1.0 nM. SID 26681509 is determined to be a slow-binding and slowly reversible competitive inhibitor. Through a transient kinetic analysis for single-step reversibility, inhibition rate constants are kon = 24,000 M-1s-1 and koff = 2.2 × 10-5 s-1 (Ki = 0.89 nM). Molecular docking studies are undertaken using the experimentally-derived X-ray crystal structure of papain/CLIK-148[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
SID 26681509 treatment significantly improves survival in murine models of sepsis and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
539.65 |
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Formula |
C27H33N5O5S |
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CAS 号 |
958772-66-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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