上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
BAY1238097 纯度: 98.55%
BAY1238097 是一种有效的、BET 与组蛋白 结合的选择性抑制剂,通过下调c-Myc水平及下游转录组,在AML (急性髓性白血病) 和MM (多发性骨髓瘤) 模型中表现出较强的抗增殖活性 (IC50 值 <100 nM)。
BAY1238097 Chemical Structure
CAS No. : 1564268-08-1
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥2090 | In-stock | |
5 mg | ¥1900 | In-stock | |
10 mg | ¥2900 | In-stock | |
50 mg | ¥11000 | In-stock | |
100 mg | ¥19500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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BAY1238097 相关产品
•相关化合物库:
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Histone Modification Research Compound Library
- Anti-Cancer Compound Library
- Clinical Compound Library
- Reprogramming Compound Library
- Anti-Blood Cancer Compound Library
生物活性 |
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM). |
IC50 & Target |
IC50: < 100 nM (BET in a TR-FRET assay)[1]. |
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体外研究 (In Vitro) |
BAY 1238097 shows strong inhibitory activity (IC50 < 100 nM) in a TR-FRET assay using BET BRD4 bromodomain 1 and an acetylated peptide derived from histone H4. In the NanoBRET assay, the interaction between BRD4 (IC50=63 nM), BRD3 or BRD2 (IC50=609 nM) and H4 (IC50=2430 nM) is inhibited[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
BAY 1238097 shows strong efficacy in the AML and MM models. BAY 1238097 has in vivo anti-tumour activity in lymphoma models[1][2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
451.56 |
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Formula |
C25H33N5O3 |
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CAS 号 |
1564268-08-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 150 mg/mL (332.18 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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