(+)-JQ1 PA

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(+)-JQ1 PA  纯度: 98.87%

(+)-JQ1 PA 是溴结构域和额外末端结构域 (BET) 抑制剂 JQ1 的衍生物，其 IC50 值为 10.4 nM。

(+)-JQ1 PA

(+)-JQ1 PA Chemical Structure

CAS No. : 2115701-93-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Ethanol ￥1540 In-stock
5 mg ￥1400 In-stock
10 mg ￥2200 In-stock
25 mg ￥4200 In-stock
50 mg ￥7100 In-stock
100 mg ￥13000 In-stock
200 mg   询价  
500 mg   询价  

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(+)-JQ1 PA 相关产品

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生物活性

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.

IC50 & Target

10.4 nM (BET)[1].
体外研究
(In Vitro)

(+)-JQ1 PA is a derivative of JQ1, which is the inhibitor of BET. The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

437.95

Formula

C22H20ClN5OS
CAS 号

2115701-93-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Ethanol : 50 mg/mL (114.17 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2834 mL 11.4168 mL 22.8337 mL
5 mM 0.4567 mL 2.2834 mL 4.5667 mL
10 mM 0.2283 mL 1.1417 mL 2.2834 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.
Cell Assay
[1]

Proliferation of MV4;11 cells after 72 hours of treatment, comparing JQ1 versus JQ1-PA are tested. Cell cycle profile of MV4;11 cells after 48 hours of treatment with DMSO, JQ1, JQ1-PA, or JQ1-TCO (all compounds used at 500 nM) are tested[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.

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