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DTHIB 纯度: 98.34%
DTHIB 是一种直接和选择性的 heat shock factor 1 (HSF1) 抑制剂,DTHIB 与 HSF1 DNA 结合域结合的 Kd 为 160 nM。DTHIB 抑制 HSF1 癌症基因标记 (HSF1 CaSig),并选择性刺激核 HSF1 的降解。DTHIB 具有有效的抗癌活性,可用于前列腺癌的研究。
DTHIB Chemical Structure
CAS No. : 897326-30-6
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DTHIB 相关产品
•相关化合物库:
- Covalent Screening Library Plus
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Covalent Screening Library
- Cytoskeleton Compound Library
- Transcription Factor Targeted Library
生物活性 |
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research[1]. |
IC50 & Target |
Kd: 160 nM (DTHIB binding to the HSF1 DNA binding domain)[1] |
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体外研究 (In Vitro) |
DTHIB (5 μM; 48 hours) treatment of C4-2 cells induces cell cycle arrest, with accumulation in the G1 phase. DTHIB stimulates C4-2 PCa cell entry into senescence[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
DTHIB (5 mg/kg; intraperitoneal injection; daily; for 3 weeks) treatment potently attenuates tumor progression in a C4-2 xenograft mouse model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
309.68 |
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Formula |
C13H9ClFN3O3 |
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CAS 号 |
897326-30-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (322.91 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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