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Pantoprazole sodium (Synonyms: 泮托拉唑钠; BY1023 sodium; SKF96022 sodium) 纯度: 99.89%
Pantoprazole sodium (BY1023 sodium) 是一种具有口服活性的,有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole sodium 是一种取代的苯并咪唑,是一种有效的 H+/K+-ATPase 抑制剂,IC50 为 6.8 μM。Pantoprazo sodium 可以改善 pH 值稳定性,并具有抗分泌,抗溃疡的作用。Pantoprazo sodium 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。
Pantoprazole sodium Chemical Structure
CAS No. : 138786-67-1
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥500 | In-stock | |
100 mg | ¥400 | In-stock | |
500 mg | ¥1400 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
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生物活性 |
Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole sodium, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4]. |
IC50 & Target |
proton pump |
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体外研究 (In Vitro) |
Pantoprazole sodium (BY1023 sodium; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Pantoprazole sodium (BY1023 sodium; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
405.35 |
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Formula |
C16H14F2N3NaO4S |
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CAS 号 |
138786-67-1 |
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中文名称 |
泮托拉唑钠;潘托拉唑钠 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (246.70 mM) H2O : 3.85 mg/mL (9.50 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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