Aurothioglucose(Synonyms: 金硫葡萄糖; Gold thioglucose)

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Aurothioglucose (Synonyms: 金硫葡萄糖; Gold thioglucose)

Aurothioglucose (Gold thioglucose) 是众所周知的TrxR1活性位点抑制剂，它能抑制hela细胞中的 TrxR1活性同时对细胞活性无影响。

Aurothioglucose(Synonyms: 金硫葡萄糖; Gold thioglucose)

Aurothioglucose Chemical Structure

CAS No. : 12192-57-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1595 In-stock
5 mg ￥1450 In-stock
10 mg ￥2450 In-stock
50 mg   询价  
100 mg   询价  

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Aurothioglucose 相关产品

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生物活性

Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells. IC50 value: Target: TrxR1 in vitro: Trx1 redox state and ROS generation were measured in cells exposed to the TrxR1 inhibitors aurothioglucose (ATG) and monomethylarsonous acid (MMA(III)) and in cells depleted of TrxR1 activity by siRNA knock down [1]. in vivo: Adult mice received a single intratracheal dose of 0.375 μg/g lipopolysaccharide (LPS) 12 h before a single intraperitoneal injection of 25 mg/kg ATG. Control mice received intratracheal and/or intraperitoneal saline. ATG treatment significantly attenuated lung injury, increased lung GCLM expression and GSH levels, and decreased mortality. GSH depletion completely prevented the protective effects of ATG in LPS/hyperoxia-exposed mice [2].

分子量

392.18

Formula

C6H11AuO5S
CAS 号

12192-57-3
中文名称

葡糖硫金；金硫葡糖；金硫葡萄糖；硫代葡糖金
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 125 mg/mL (318.73 mM; Need ultrasonic)

DMSO : 6 mg/mL (15.30 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5498 mL 12.7492 mL 25.4985 mL
5 mM 0.5100 mL 2.5498 mL 5.0997 mL
10 mM 0.2550 mL 1.2749 mL 2.5498 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Watson WH, et al. Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):832-6.

    [2]. Britt RD Jr, et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10;20(17):2681-91.

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