GDC-0927 Racemate(Synonyms: SRN-927 Racemate)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GDC-0927 Racemate (Synonyms: SRN-927 Racemate)

GDC-0927 Racemate (SRN-927 Racemate) 是雌激素受体 (estrogen receptor) 的降解剂，能够有效抑制 ER-α 的活性，IC50 值为 0.2 nM，可用于雌激素受体有关的疾病。

GDC-0927 Racemate(Synonyms: SRN-927 Racemate)

GDC-0927 Racemate Chemical Structure

CAS No. : 1443983-36-5

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生物活性

GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases.

IC50 & Target

IC50: 0.2 nM (ER-α)[1]
体外研究
(In Vitro)

GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

461.52

Formula

C28H28FNO4
CAS 号

1443983-36-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mehmet Kahraman, et al. Estrogen receptor modulator and uses thereof. WO2014205138A1.

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