27-TBDMS-4-Dehydrowithaferin A | whatman (沃特曼)

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27-TBDMS-4-Dehydrowithaferin A

27-TBDMS-4-Dehydrowithaferin A 是一种叶黄素 A 衍生物，对肿瘤细胞具有强大的抗增殖作用。27-TBDMS-4-Dehydrowithaferin A 诱导肿瘤细胞凋亡。27-TBDMS-4-Dehydrowithaferin A 是一种抗癌剂。

27-TBDMS-4-Dehydrowithaferin A Chemical Structure

CAS No. : 1214886-31-3

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生物活性	27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent^[1].
体外研究 (In Vitro)	27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC₅₀=1.7 μM), A-549 (IC₅₀=5.3 μM), MCF-7 (IC₅₀=0.5 μM), and normal Vero cells (IC₅₀=3.1 μM)^[1]. 27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells^[1]. 27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	582.84
Formula	C₃₄H₅₀O₆Si
CAS 号	1214886-31-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.

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