7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

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7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol 

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol 是一种苯并芘衍生物，可被肝细胞溶胶活化成亲电硫酸酯，能够形成共价 DNA 加合物并诱导突变。

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol Chemical Structure

CAS No. : 6272-55-5

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生物活性

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters[1], which are capable of forming covalent DNA adducts and inducing mutations[2].

分子量

272.34

Formula

C20H16O
CAS 号

6272-55-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 1994 Nov;15(11):2605-11.

    [2]. Surh YJ, Tannenbaum SR. Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene. Chem Res Toxicol. 1995 Jul-Aug;8(5):693-8.

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