Balsalazide sodium hydrate(Synonyms: 巴柳氮钠水合物; Balsalazide disodium dihydrate)

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Balsalazide sodium hydrate (Synonyms: 巴柳氮钠水合物; Balsalazide disodium dihydrate)

Balsalazide sodium hydrate 可通过调节 IL-6/STAT3 通路来发挥相关的抑癌作用。

Balsalazide sodium hydrate(Synonyms: 巴柳氮钠水合物; Balsalazide disodium dihydrate)

Balsalazide sodium hydrate Chemical Structure

CAS No. : 150399-21-6

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Balsalazide sodium hydrate 的其他形式现货产品:

Balsalazide

生物活性

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

IC50 & Target[1][2]

IL-6

 

STAT3

 

体内研究
(In Vivo)

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

437.31

Formula

C17H17N3Na2O8
CAS 号

150399-21-6
中文名称

巴柳氮钠水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.

    [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

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