Finasteride acetate(Synonyms: 醋酸非那雄胺; MK-906 acetate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Finasteride acetate (Synonyms: 醋酸非那雄胺; MK-906 acetate)

Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂，对 II 型 5α-还原酶的 IC50 值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。

Finasteride acetate(Synonyms: 醋酸非那雄胺; MK-906 acetate)

Finasteride acetate Chemical Structure

CAS No. : 222989-99-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Finasteride acetate 的其他形式现货产品:

Finasteride

生物活性

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

IC50 & Target

IC50: 4.2 nM (type II 5α-reductase)[1]
体外研究
(In Vitro)

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: PC-3, DU-145, and LNCaP cells
Concentration: 10 μM
Incubation Time: 6, 12, 24 h
Result: Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.

体内研究
(In Vivo)

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)[3]
Dosage: 0.1-0.5 mg/kg
Administration: P.o. once daily for 16 weeks
Result: Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.

Clinical Trial

分子量

432.60

Formula

C25H40N2O4
CAS 号

222989-99-3
中文名称

醋酸非那雄胺；醋酸非那斯特萊
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Flores E, et, al. Steroid 5alpha-reductase inhibitors. Mini Rev Med Chem. 2003 May;3(3):225-37.

    [2]. Yun DK, et, al. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomol Ther (Seoul). 2013 Jan;21(1):49-53.

    [3]. Sirinarumitr K, et, al. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. J Am Vet Med Assoc. 2001 Apr 15;218(8):1275-80.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务