Tutuilamide A

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tutuilamide A 

Tutuilamide A 是一种有效的猪胰弹性蛋白酶 (PPE) 抑制剂,IC50 值为 1.2 nM。Tutuilamide A 还抑制人中性粒细胞弹性蛋白酶 (HNE; IC50=0.73 nM) 和激肽释放酶 7 (KLK7; IC50=5.0 nM)。

Tutuilamide A

Tutuilamide A Chemical Structure

CAS No. : 2756129-42-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM)[1].

IC50 & Target

IC50: 1.2 nM (porcine pancreatic elastase), 0.73 nM (human neutrophil elastase), 5.0 nM (kallikrein 7)[1]

分子量

1021.59

Formula

C51H69ClN8O12

CAS 号

2756129-42-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chen QY, et, al. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7. Bioorg Med Chem. 2020 Dec 1;28(23):115756.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务