PD-1/PD-L1-IN-24

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PD-1/PD-L1-IN-24 

PD-1/PD-L1-IN-24 是一种高效的 PD-1/PD-L1 抑制剂,IC50 为 1.57 nM。PD-1/PD-L1-IN-24 通过提高 IFN-γ 来在细胞水平上恢复 T 细胞功能。PD-1/PD-L1-IN-24 对 PBMCs 具有较低的细胞毒性。

PD-1/PD-L1-IN-24

PD-1/PD-L1-IN-24 Chemical Structure

CAS No. : 2667680-33-1

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生物活性

PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs[1].

IC50 & Target

IC50: 1.57 nM (PD-1/PD-L1)[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM[1].
PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC50 is 12.42 μM[1].
PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line: PBMC[1]
Concentration: 0.003, 0.0091, 0.027, 0.082, 0.247, 0.741, 2.222, 6.67 and 20 μM
Incubation Time: 72 hours
Result: No significant toxicity was observed at concentrations ranging from 0.003 to 2.22 μM, and the IC50 was 12.42 μM.

分子量

640.08

Formula

C34H30ClN5O6

CAS 号

2667680-33-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang Y, Kun Huang, Gao Y, et al. Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction. Eur J Med Chem. 2022;229:113998.

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