Epiblastin A

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Epiblastin A 

Epiblastin A 是一种 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂,对 CK1α, CK1δ, 和CK1 ɛ 的 IC50 分别为 8.9, 0.5,和 4.7 µM。Epiblastin A 通过抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。

Epiblastin A

Epiblastin A Chemical Structure

CAS No. : 16470-02-3

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生物活性

Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1[1].

分子量

287.71

Formula

C12H10ClN7

CAS 号

16470-02-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Andrei Ursu, et al. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol. 2016 Apr 21;23(4):494-507.

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