EZH2-IN-9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EZH2-IN-9 

EZH2-IN-9 是一种有效的 EZH2 抑制剂。EZH2 过表达或 SET 区突变 (Y641F、Y641N、A687V、A677G 点突变) 均导致 H3K27me3 异常升高，促进多种肿瘤的生长发育，如乳腺癌、前列腺癌、白血病等。EZH2-IN-9 具有研究癌症疾病的潜力 (摘自专利 WO2021180235A1，化合物 17)。

EZH2-IN-9

EZH2-IN-9 Chemical Structure

CAS No. : 2700897-24-9

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生物活性

EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17)[1].

分子量

596.09

Formula

C28H32ClF2N3O5S
CAS 号

2700897-24-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Yao, et al. Zeste enhancer homologue 2 inhibitor and its use. Patent WO2021180235A1.

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