Snail/HDAC-IN-1 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Snail/HDAC-IN-1

Snail/HDAC-IN-1是一种有效的 Snail/HDAC 双靶点抑制剂。Snail/HDAC-IN-1 对 HDAC1 有较强的抑制活性，IC₅₀ 为0.405 μM，对 Snail 有较强的抑制作用，K_d 为 0.18 μM。Snail/HDAC-IN-1 增加 HCT-116 细胞中的组蛋白 H4 乙酰化，并降低 Snail 蛋白的表达，从而诱导细胞凋亡 (apoptosis)。

Snail/HDAC-IN-1 Chemical Structure

CAS No. : 2415281-52-4

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生物活性

Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC₅₀ of 0.405 μM and potent inhibition against Snail with a K_d of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis^[1].

IC₅₀ & Target^[1]

HDAC1

0.405 μM (IC₅₀)

Snail

0.18 μM (Kd)

体外研究
(In Vitro)

Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC₅₀ of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI₅₀=0.0488 μM), MDA-MB-435 (GI₅₀=0.0361 μM), and MCF7 (GI₅₀=0.0518 μM)^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

488.54

Formula

C₂₄H₂₁FN₈OS

CAS 号

2415281-52-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Cui H, et al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. Eur J Med Chem. 2022;229:114082.

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