AK-778-XXMU

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

AK-778-XXMU 

AK-778-XXMU是DNA结合2 (ID2) 拮抗剂的有效抑制剂,KD为129 nM。AK-778-XXMU 能抑制胶质瘤细胞株的迁移和侵袭,诱导细胞凋亡 (apoptosis),更重要的是能减缓肿瘤生长。

AK-778-XXMU

AK-778-XXMU Chemical Structure

CAS No. : 1227045-76-2

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生物活性

AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth[1].

分子量

392.83

Formula

C22H17ClN2O3

CAS 号

1227045-76-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhong G, et al. Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma. Bioorg Med Chem. 2021;49:116427.

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