上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Cicaprost (Synonyms: ZK 96480)
Cicaprost (ZK 96480) 是一种前列环素受体 (IP) 激动剂。Cicaprost可引起动脉的浓度依赖性舒张,EC50 为 5.8 nM 。
Cicaprost Chemical Structure
CAS No. : 94079-80-8
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生物活性 |
Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]。 |
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体外研究 (In Vitro) |
Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
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体内研究 (In Vivo) |
Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice[4]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
374.47 |
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Formula |
C22H30O5 |
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CAS 号 |
94079-80-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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