Cicaprost(Synonyms: ZK 96480)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Cicaprost (Synonyms: ZK 96480)

Cicaprost (ZK 96480) 是一种前列环素受体 (IP) 激动剂。Cicaprost可引起动脉的浓度依赖性舒张,EC50 为 5.8 nM 。

Cicaprost(Synonyms: ZK 96480)

Cicaprost Chemical Structure

CAS No. : 94079-80-8

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生物活性

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]

体外研究
(In Vitro)

Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM[2].
Cicaprost stimulates [3H]cyclic AMP production with EC50 values of 1.5-22 nM, and stimulates [3H]inositol phosphate production (EC50 values 49-457 nM) in all but the SK-N-SH cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: HPASMC
Concentration: 10 pM, 100 pM, 1 nM, 10 nM, 100 nM, 1 μM, and 10 μM
Incubation Time:
Result: Dose-dependently inhibited proliferation with an EC50 of 24.1 nM.

体内研究
(In Vivo)

Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (+/+) and IP−/− mice[4]
Dosage: 1 μg/kg
Administration: Intravenous injection
Result: Caused hypotension of ∼30 mm Hg in anaesthetized wild-type mice, whereas there was no change in blood pressure in IP-deficient mice even at 10 μg/kg.

分子量

374.47

Formula

C22H30O5

CAS 号

94079-80-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nicole Ferko, et al. NO synergism with cicaprost in the canine pulmonary artery. BioPharm Journal ONLINE 2:2 (1998).

    [2]. Lucie H Clapp, et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol. 2002 Feb;26(2):194-201.

    [3]. Kevin B S Chow, et al. Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent. Eur J Pharmacol. 2003 Aug 1;474(1):7-13.

    [4]. T Murata, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 1997 Aug 14;388(6643):678-82.

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