EGFR-IN-30

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-30 

EGFR-IN-30 是一种有效的 EGFR 抑制剂，对 EGFR (WT)、EGFR (L858R/T790M/C797S) 的 IC50 分别为 1-10 nM、<1 nM。EGFR-IN-30 具有用于细胞增殖类疾病，类如肿瘤等研究的潜力。

EGFR-IN-30

EGFR-IN-30 Chemical Structure

CAS No. : 2726463-68-7

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生物活性

EGFR-IN-30 is a potent EGFR inhibitor with IC50s of 1-10 nM, <1 nm for egfr (wt), (l858r>[1].

IC50 & Target[1]

EGFR (WT)

1-10 nM (IC50)

EGFR (L858R/T790M/C797S)

<1 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-30 (compound 27) inhibits A431 cell (IC50=100-1000 nM),Ba/F3_L858R/T790M/C797S cell (IC50<10 nm), ba>50<10 nm)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

610.49

Formula

C28H33BrN7O2P
CAS 号

2726463-68-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shansong Zheng, et al. Tricyclic compounds as EGFR inhibitors. WO2021208918A1.

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