Aurora A/PKC-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aurora A/PKC-IN-1 

Aurora A/PKC-IN-1 (Compound 2e) 是一种有效的 Aurora A (AurA) 和PKC (α, β1, β2, θ) 双效抑制剂，对 AurA 和 PKCα 分别具有 6.9 nM 和 16.9 nM。Aurora A/PKC-IN-1对乳腺癌细胞具有抗增殖和抗转移活性。

Aurora A/PKC-IN-1

Aurora A/PKC-IN-1 Chemical Structure

CAS No. : 2143100-98-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

IC50 & Target[1]

Aurora A

6.9 nM (IC50)

PKCα

16.9 nM (IC50)

分子量

464.24

Formula

C16H14N6OSe2
CAS 号

2143100-98-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务