Vinaxanthone(Synonyms: SM-345431)

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Vinaxanthone (Synonyms: SM-345431)

Vinaxanthone (SM-345431) 是一种有效的选择性 semaphorin3A 抑制剂。Vinaxanthone 抑制 semaphorin3A 活性，IC50 为 0.1-0.2 μM。Vinaxanthone 对大鼠脑中、小鼠结肠 26 腺癌和小鼠成纤维细胞 NIH3T3的磷脂酶 C (PLC) 具有选择性抑制活性，IC50 分别为 5.4、9.3 和 44 μM。

Vinaxanthone(Synonyms: SM-345431)

Vinaxanthone Chemical Structure

CAS No. : 133293-89-7

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生物活性

Vinaxanthone (SM-345431) is a potent and selective semaphorin3A inhibitor. Vinaxanthone exhibits semaphorin3A inhibiting activity with an IC50 of 0.1-0.2 μM[1]. Vinaxanthone shows selective inhibitory activity against phospholipase C (PLC) from rat brain, mutine colon 26 Adenocarcinoma and murine fibroblasts NIH3T3 with IC50s being 5.4, 9.3 and 44 μM, respectively[2].

分子量

576.42

Formula

C28H16O14
CAS 号

133293-89-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Masahiro Aoki, et al. Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum. Tetrahedron Letters. 1991, 32 (36):4737-4740.

    [2]. Liang Zhang, et al. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7:14.

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