Tilomisole(Synonyms: Wy 18251)

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Tilomisole (Synonyms: Wy 18251)

Tilomisole (Wy 18251) 是一种具有抗炎活性的苯并咪唑噻唑实验药物。与左旋咪唑相比，Tilomisole 引起的粒细胞缺乏症较少，但保留了免疫调节能力。Tilomisole 口服有效。Tilomisole 具有研究癌症和炎症的潜力。

Tilomisole(Synonyms: Wy 18251)

Tilomisole Chemical Structure

CAS No. : 58433-11-7

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生物活性

Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

分子量

342.80

Formula

C17H11ClN2O2S
CAS 号

58433-11-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14.

    [2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

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