6,8-Diprenylnaringenin(Synonyms: Lonchocarpol A; Senegalensin)

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6,8-Diprenylnaringenin (Synonyms: Lonchocarpol A; Senegalensin)

6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin) 是一种啤酒花异戊二烯黄酮类化合物,是乳腺癌抗性蛋白 (ABCG2) 的抑制剂。具有一定的雌激素作用,但其效力不到 8-Prenylnaringenin 的 1%。在 HEK293 细胞中抑制 ABCG2 介导的 Mitoxantrone 流出和 3H-Methotrexate 转运 (IC50=0.41 μM)。Prenylnaringenin 具有一定的雌激素作用,但其效力不到 8-Prenylnaringenin 的 1%。

6,8-Diprenylnaringenin(Synonyms: Lonchocarpol A;  Senegalensin)

6,8-Diprenylnaringenin Chemical Structure

CAS No. : 68236-11-3

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生物活性

6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].

分子量

408.49

Formula

C25H28O5

CAS 号

68236-11-3

中文名称

6,8-二异戊二烯基柚皮素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110.

    [2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5.

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