IMPDH2-IN-2

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IMPDH2-IN-2 

IMPDH2-IN-2 是一种有效的肌苷 5′-单磷酸脱氢酶 (IMPDH) 抑制剂，Ki,app 值分别为 14 μM。IMPDH2-IN-2 显示出中等的抗菌活性 (MIC = 6.3 和 11 μM，分别在最小 GAST/Fe 和丰富的 7H9/ADC/Tween 培养基中)。IMPDH2-IN-2 是一种潜在的抗结核药物。

IMPDH2-IN-2

IMPDH2-IN-2 Chemical Structure

CAS No. : 1434517-02-8

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生物活性

IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].

IC50 & Target

IMPDH[1]
分子量

428.27

Formula

C21H15Cl2N3O3
CAS 号

1434517-02-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chacko S, et al. Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756.

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