Delta-12-Prostaglandin J2(Synonyms: Δ12-PGJ2)

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Delta-12-Prostaglandin J2 (Synonyms: Δ12-PGJ2)

Delta-12-Prostaglandin J2 (Δ12-PGJ2) 是一种环戊烯酮前列腺素 (PG)，对多种肿瘤细胞的生长具有抗增殖作用。Delta-12-Prostaglandin J2 是前列腺素 D2 的天然脱水产物，能够通过 caspase 激活诱导 HeLa 细胞的凋亡 (apoptosis)。

Delta-12-Prostaglandin J2(Synonyms: Δ12-PGJ2)

Delta-12-Prostaglandin J2 Chemical Structure

CAS No. : 87893-54-7

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生物活性

Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

分子量

334.45

Formula

C20H30O4
CAS 号

87893-54-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36(5):444-453.

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