SHP2 protein degrader-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SHP2 protein degrader-1 

SHP2 protein degrader-1 是一种有效的 SHP2 变构抑制剂。SHP2 蛋白降解剂-1 诱导 SHP2 降解和细胞凋亡。SHP2 蛋白降解剂-1 具有研究 SHP2 相关疾病的潜力。

SHP2 protein degrader-1

SHP2 protein degrader-1 Chemical Structure

CAS No. : 2624181-69-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases[1].

IC50 & Target

SHP2[1]
体外研究
(In Vitro)

SHP2 protein degrader-1 (compound SP4) (0-200 μM; 24 hours) inhibits the growth of Hela cells, with IC50 of 5.77 and 4.30 nM, respectively, which are about 100 times higher than the activity of SHP099 (SHP2 inhibitor)[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces 54.01% apoptotic death compared with 0.13% of the control at 100 nM[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces cell cycle arrested at the G1 phase in Hela cells[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) significantly inhibits the phosphorylation of JNK, Erk and p38[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) inhibits RAS/MAPK signaling and cellular responses by a mechanism involving inhibition of SHP2 catalytic activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Hela cells
Concentration: 0-200  μM
Incubation Time: 24 hours
Result: Strongly inhibited the growth of Hela cells, with IC50 of 5.77 and 4.30 nM, respectively, which were about 100 times higher than the activity of SHP099 (SHP2 inhibitor).

Apoptosis Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Induced 54.01% apoptotic death compared with 0.13% of the control at 100 nM. While SHP099 at 1000 nM could induce 33.74% apoptotic death compared with 0.13% of the control.

Cell Cycle Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Induced cell cycle arrested at the G1 phase in Hela cells.

Western Blot Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the phosphorylation of JNK, Erk and p38.

分子量

908.83

Formula

C42H51Cl2N11O8
CAS 号

2624181-69-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zheng M, et al. Novel PROTACs for degradation of SHP2 protein. Bioorg Chem. 2021;110:104788.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务