Flurocitabine(Synonyms: 5-Fluorocyclocytidine; 5′-Fluorocyclocytidine)

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Flurocitabine (Synonyms: 5-Fluorocyclocytidine; 5′-Fluorocyclocytidine)

Flurocitabine (5-Fluorocyclocytidine) 是阿糖胞苷的氟化酸酐类似物，在体内部分水解成两种活性抗肿瘤物质 (阿拉伯糖基-氟尿嘧啶 (ara-FC) 和阿拉伯糖基-氟尿嘧啶 (ara-FU))。Flurocitabine (5-Fluorocyclocytidine) 在急性白血病和实体瘤的 I 期研究中具有抗肿瘤活性。

Flurocitabine(Synonyms: 5-Fluorocyclocytidine; 5

Flurocitabine Chemical Structure

CAS No. : 37717-21-8

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生物活性

Flurocitabine (5-Fluorocyclocytidine) is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine (5-Fluorocyclocytidine) has antitumor activity during phase I studies in acute leukemia and solid tumors[1].

分子量

243.19

Formula

C9H10FN3O4
CAS 号

37717-21-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14(2):195-201.

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