CYPMPO

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CYPMPO 

CYPMPO 是一种自旋捕捉剂。CYPMPO 是一种环状 DEPMPO 型硝酮,用于评估对羟基和超氧自由基的自旋捕获能力。抗氧化和抗肿瘤活性。

CYPMPO

CYPMPO Chemical Structure

CAS No. : 934182-09-9

规格 是否有货
1 mg 询价

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生物活性

CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].

体外研究
(In Vitro)

DMPO is often used as a spin trapping agent to detect oxygen-centered radicals. CYPMPO has a larger reaction rate constant with superoxide anion than DMPO and the superoxide adduct of CYPMPO is more stable than that of DMPO. CYPMPO (2.5 mM) acts as a spin-trap agent[2].
CYPMPO, a spin-trap, a cyclic DEPMPO-like nitrone trap, may provide new free radical information when used with mitochondria. CYPMPO has the preferential quality of having minimal mitochondrial toxicity at concentrations required for radical detection[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

247.23

Formula

C10H18NO4P

CAS 号

934182-09-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Masato Kamibayashi, et al. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res. 2006 Nov;40(11):1166-72.

    [2]. Ryohei Umeda, et al. Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors. J Clin Biochem Nutr. 2019 Jan;64(1):20-26.

    [3]. Matsuzaki S, et al. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 2011, 50, 50, 10792-10803.

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