Amifostine thiol-d4 dihydrochloride

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Amifostine thiol-d4 dihydrochloride 

Amifostine thiol-d4 dihydrochloride 是 Amifostine thiol dihydrochloride 的氘代物。Amifostine thiol (WR-1065) dihydrochloride 可以保护正常组织免受某些癌症药物的毒性作用,并通过 JNK 依赖性信号通路激活 p53

Amifostine thiol-d4 dihydrochloride

Amifostine thiol-d4 dihydrochloride Chemical Structure

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生物活性

Amifostine thiol-d4 dihydrochloride is the deuterium labeled Amifostine thiol dihydrochloride. Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

210.07

Formula

C5H11D4ClN2S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.

    [3]. Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73.

    [4]. Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.

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