(3S,5R)-Fluvastatin-d7 sodium(Synonyms: (3S,5R)-XU 62-320-d7 sodium)

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(3S,5R)-Fluvastatin-d7 sodium (Synonyms: (3S,5R)-XU 62-320-d7 sodium)

(3S,5R)-Fluvastatin-d7 sodium ((3S,5R)-XU 62-320-d7 sodium) 是 (3S,5R)-Fluvastatin sodium 的氘代物。(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) 是 Fluvastatin 的 (3S,5R) 对映体。Fluvastatin 是第一个完全合成的,竞争性的 HMG-CoA reductase 还原酶抑制剂,IC50 为 8

(3S,5R)-Fluvastatin-d7 sodium(Synonyms: (3S,5R)-XU 62-320-d7 sodium)

(3S,5R)-Fluvastatin-d7 sodium Chemical Structure

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生物活性

(3S,5R)-Fluvastatin-d7 sodium ((3S,5R)-XU 62-320-d7 sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

440.49

Formula

C24H18D7FNNaO4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

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