Thymidine 3′,5′-disphosphate(Synonyms: Deoxythymidine 3′,5′-diphosphate; pdTp)

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Thymidine 3′,5′-disphosphate (Synonyms: Deoxythymidine 3′,5′-diphosphate; pdTp)

Thymidine 3′,5′-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) 是一种选择性 SND1 (miRNA调控复合体RISC亚基) 的小分子抑制剂，可抑制 SND1 活性。Thymidine 3′,5′-disphosphate 是一种抗肺癌试剂，在体内表现出抗肿瘤活性。

Thymidine 3

Thymidine 3′,5′-disphosphate Chemical Structure

CAS No. : 2863-04-9

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生物活性

Thymidine 3′,5′-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of SND1 (the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3′,5′-disphosphate is an anti-HCC agent and exhibits anti-tumor efficacy in vivo[1].

IC50 & Target

IC50: SND1[1]
分子量

402.19

Formula

C10H16N2O11P2
CAS 号

2863-04-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316.

    [2]. Byoung Kwon Yoo, et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology. 2011 May;53(5):1538-48.

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