MI-192

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MI-192 

MI-192 是一种选择性 HDAC2 和 HDAC3 抑制剂，IC50 分别为 30 nM 和 16 nM。MI-192 对 HDAC2/3 的选择性比其他 HDAC 异构体更高。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。

MI-192

MI-192 Chemical Structure

CAS No. : 1415340-63-4

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生物活性

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

体外研究
(In Vitro)

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HL60 and Kasumi-1 cells
Concentration: 150 nM, 300 nM, 500 nM, 1 μM
Incubation Time: 72 h
Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.

体内研究
(In Vivo)

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)[2]
Dosage: 40 mg/kg
Administration: i.p; once a day; for 3 days
Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.

分子量

383.44

Formula

C24H21N3O2
CAS 号

1415340-63-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10.

    [2]. S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):239-248.

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