Cobomarsen(Synonyms: MRG-106)

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Cobomarsen (Synonyms: MRG-106)

Cobomarsen (MRG-106) 是 miR-155 的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK 和 PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

Cobomarsen(Synonyms: MRG-106)

Cobomarsen Chemical Structure

CAS No. : 1848257-52-2

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生物活性

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2].

体外研究
(In Vitro)

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 48, 72, 96 hours
Result: Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Triggered a significant induction of late apoptosis in all cell lines.

体内研究
(In Vivo)

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage: 1 mg/kg
Administration: I.v. on days 0, 2, 4, and 7
Result: Reduced tumor growth most significantly at day 7 and day 10.

CAS 号

1848257-52-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.

    [2]. Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.

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