Boc-bipiperidine-ethynylbenzoic acid

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Boc-bipiperidine-ethynylbenzoic acid 

Boc-bipiperidine-ethynylbenzoic acid 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子 ARD-61。

Boc-bipiperidine-ethynylbenzoic acid

Boc-bipiperidine-ethynylbenzoic acid Chemical Structure

CAS No. : 2308497-81-4

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生物活性

Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].

IC50 & Target[1]

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

412.52

Formula

C24H32N2O4

CAS 号

2308497-81-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532.

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