Fostroxacitabine bralpamide(Synonyms: MIV-818)

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Fostroxacitabine bralpamide (Synonyms: MIV-818)

Fostroxacitabine bralpamide (MIV-818) 是一种具有口服活性的基于 Troxacitabine 的核苷酸前药,具有抗癌作用。

Fostroxacitabine bralpamide(Synonyms: MIV-818)

Fostroxacitabine bralpamide Chemical Structure

CAS No. : 2129993-56-0

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生物活性

Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects[1].

体外研究
(In Vitro)

Fostroxacitabine bralpamide (MIV-818) is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver. The tri-phosphate is incorporated into DNA during replication, which leads to DNA double strand breaks, DNA damage responses, and cytotoxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

589.37

Formula

C22H30BrN4O8P

CAS 号

2129993-56-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. T.R. Jeffry Evans, et al. Phase I study of the novel pro-drug MIV-818 in patients with hepatocellular carcinoma, intra-hepatic cholangiocarcinoma or liver metastases.

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