Mezerein(Synonyms: 密执毒素;欧瑞香脂;)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mezerein (Synonyms: 密执毒素;欧瑞香脂;)

Mezerein 是一种 PKC 激活剂,具有抗白血病特性。 Mezerein 抑制表达 PKC alpha (IC50=1190 nM)、PKC beta1 (IC50=908 nM) 和 PKC delta (IC50=141 nM) 的酵母生长,但不抑制表达 PKC 的酵母生长。

Mezerein(Synonyms: 密执毒素;欧瑞香脂;)

Mezerein Chemical Structure

CAS No. : 34807-41-5

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生物活性

Mezerein is a PKC activator that exhibits antileukemic properties. Mezerein inhibits the growth of yeast expressing PKC alpha (IC50=1190 nM), PKC beta1 (IC50=908 nM), and PKC delta (IC50=141 nM) but not of yeast expressing PKC[1][2].

体外研究
(In Vitro)

Mezerein is an antileukemic principle isolated from Daphne mezereum L[2].
Mezerein (50 ng/mL; 72 hours) potently inhibit tumorigenic murine macrophage cell line M5076 cellular proliferation[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: M5076 cells
Concentration: 50 ng/mL
Incubation Time: 72 hours
Result: Inhibited cellular proliferation (by greater than 90%).

体内研究
(In Vivo)

Mezerein exhibits antileukemic activity against the P-388 lymphocytic leukemia in mice. Mezerein (50 μg/kg) shows significant inhibitory activity against the P-388 and L-1210 leukemias in mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

654.70

Formula

C38H38O10

CAS 号

34807-41-5

中文名称

密执毒素;欧瑞香脂;

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. L Saraiva, et al. Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta. Planta Med. 2001 Dec;67(9):787-90.

    [2]. S M Kupchan,et al.Mezerein: antileukemic principle isolated from Daphne mezereum L. Science. 1975 Feb 21;187(4177):652-3.

    [3]. N T Goode, et al. Protein kinase C-induced stimulation or inhibition of cellular proliferation in a murine macrophage tumor cell line. Cancer Res. 1990 Mar 15;50(6):1828-33.

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