Rapanone(Synonyms: 拉帕酮)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Rapanone (Synonyms: 拉帕酮) 纯度: 99.20%

Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用,包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂,IC50 值为 2.6 μM。

Rapanone(Synonyms: 拉帕酮)

Rapanone Chemical Structure

CAS No. : 573-40-0

规格 价格 是否有货 数量
5 mg ¥1200 In-stock
10 mg ¥1700 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Rapanone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antibacterial Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Antiparasitic Compound library
  • Lipid Metabolism Compound Library

生物活性

Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].

IC50 & Target[4]

PLA2

2.6 μM (IC50)

体外研究
(In Vitro)

Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively[1].
Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells[1].
Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

322.44

Formula

C19H30O4

CAS 号

573-40-0

中文名称

拉帕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Andreu GLP, et, al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death. Toxicol In Vitro. 2020 Mar;63:104737.

    [2]. Morais LS, et, al. Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action. PLoS One. 2020 Nov 6;15(11):e0241855.

    [3]. Vega-Hernández K, et, al. Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities. J Inorg Biochem. 2017 May;170:134-147.

    [4]. Ospina LF, et, al. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med. 2001 Dec;67(9):791-5.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务