Cleistanthin B(Synonyms: Diphyllin O-glucoside)

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Cleistanthin B (Synonyms: Diphyllin O-glucoside) 纯度: ≥99.0%

Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用,EC50 值为 6.51 µM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

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1 mg ¥6400 In-stock
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生物活性

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]

体外研究
(In Vitro)

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

542.49

Formula

C27H26O12

CAS 号

30021-77-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.

    [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.

    [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.

    [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.

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