Cu(II) protoporphyrin IX

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Cu(II) protoporphyrin IX 

Cu (II) Protoporphyrin IX 是 Zn (II) Protoporphyrin (血红素加氧酶抑制剂) 的阴性对照。血红素加氧酶与肿瘤细胞对化疗的抵抗、自由基形成和炎症的减少有关,并与血管修复有关。

Cu(II) protoporphyrin IX

Cu(II) protoporphyrin IX Chemical Structure

CAS No. : 14494-37-2

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生物活性

Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair[1][2][3].

分子量

624.19

Formula

C34H32CuN4O4

CAS 号

14494-37-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jozkowicz A, et al. Heme oxygenase-1 in tumors: is it a false friend?. Antioxid Redox Signal. 2007;9(12):2099-2117.

    [2]. Abraham NG, et al. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med. 2005;39(1):1-25.

    [3]. Kim DH, et al. Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther. 2008;325(3):833-840.

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