PR-104 sodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PR-104 sodium 

PR-104 (sodium) 是一种选择性低氧活化 DNA 交联剂,可用于多种肿瘤异种移植模型的研究。PR-104 (sodium) 作为氮芥前药物有效地转化为亲脂性更强的二硝基苯甲酰胺芥菜醇 PR-104A。

PR-104 sodium

PR-104 sodium Chemical Structure

CAS No. : 851627-80-0

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PR-104 sodium 的其他形式现货产品:

PR-104

生物活性

PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-prodrug, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].

体外研究
(In Vitro)

PR-104 (sodium) (80 μM; 1 hour; SiHa cells) shows greater suppression of radiation-induced DNA single-strand breaks under hypoxic than aerobic conditions. PR-104 (sodium) (100 μM; 1 hour; SiHa cells) results in phosphorylation of Ser139 of histone H2AX (gH2AX). PR-104 (sodium) (0.266 mmol/kg; 18 h; SiHa cells) shows activity against hypoxic cells after irradiation. PR-104 (sodium) varies in potency between cell lines, with the lowest IC50 (0.51 μmol/L) in H460 cells and highest (7.3 μmol/L) in PC3 prostate cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

PR-104 (sodium) (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (sodium) (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1nu/nu mice
Dosage: 0.56 mmol/kg (Pharmacokinetics Analysis)
Administration: I.v. or i.p.
Result: The plasma area under the curve.
Animal Model: CD1-Foxn1nu mice
Dosage: 0.23 mmol/kg
Administration: I.p.
Result: Showed antitumor activity.

Clinical Trial

分子量

601.25

Formula

C14H19BrN4NaO12PS

CAS 号

851627-80-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13(13):3922-3932.

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