Lenalidomide-5-aminomethyl

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Lenalidomide-5-aminomethyl 

Lenalidomide-5-aminomethyl 是一种基于 Lenalidomide 的 E3 泛素连接酶 cereblon (CRBN) 配体,用于募集 cereblon 蛋白。Lenalidomide-5-aminomethyl 可通过 linker 连接到蛋白质配体上形成 PROTAC。

Lenalidomide-5-aminomethyl

Lenalidomide-5-aminomethyl Chemical Structure

CAS No. : 1010100-28-3

规格 是否有货
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Lenalidomide-5-aminomethyl 的其他形式现货产品:

Lenalidomide-5-aminomethyl hydrochloride

生物活性

Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

273.29

Formula

C14H15N3O3

CAS 号

1010100-28-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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