Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Dimethyl-SGD-1882 (Synonyms: Dimethyl-PBD dimer)

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator),可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂,能抑制 DNA 复制。

Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

Dimethyl-SGD-1882 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

753.84

Formula

C44H43N5O7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务