上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PKI-166 hydrochloride
PKI-166 hydrochloride 是一种高效、选择性的,具有口服生物活性的 EGFR 酪氨酸激酶抑制剂,IC50 值为 0.7 nM。
PKI-166 hydrochloride Chemical Structure
CAS No. : 2230253-82-2
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PKI-166 hydrochloride 的其他形式现货产品:
生物活性 |
PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1]. |
IC50 & Target |
IC50: 0.7 nM (EGFR tyrosine kinase)[1] |
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体外研究 (In Vitro) |
PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
Cell Cytotoxicity Assay[1]
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体内研究 (In Vivo) |
PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
366.84 |
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Formula |
C20H19ClN4O |
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CAS 号 |
2230253-82-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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