Fusicoccin(Synonyms: Fusicoccin A)

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Fusicoccin (Synonyms: Fusicoccin A)

Fusicoccin (Fusicoccin A)，一种真菌化脓毒素，14-3-3 蛋白相互作用的稳定剂。Fusicoccin 使 H+-ATPase/14-3-3 复合物在植物中稳定，保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡，并具有抗癌活性。

Fusicoccin(Synonyms: Fusicoccin A)

Fusicoccin Chemical Structure

CAS No. : 20108-30-9

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生物活性

Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity[1][2][3][4].

体外研究
(In Vitro)

Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC50=29 mM)[3].
Fusicoccin A activates the plasma membrane H+-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC50 growth inhibitory concentration of fusicoccin A is 92 µM in the U373-MG cells and 83 µM in the Hs683 glioma cells[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

680.82

Formula

C36H56O12
CAS 号

20108-30-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Camoni L, et al. The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?. IUBMB Life. 2013;65(6):513-517.

    [2]. Doveston RG, et al. Small-molecule stabilization of the p53-14-3-3 protein-protein interaction. FEBS Lett. 2017;591(16):2449-2457.

    [3]. Kaplan A, et al. Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. Neuron. 2017;93(5):1082-1093.e5.

    [4]. Bury M, et al. Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases. Transl Oncol. 2013;6(2):112-123.

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