Taraxerol acetate(Synonyms: 醋酸蒲公英霜)

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Taraxerol acetate (Synonyms: 醋酸蒲公英霜)

Taraxerol acetate 是 COX-1COX-2 抑制剂, IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。

Taraxerol acetate(Synonyms: 醋酸蒲公英霜)

Taraxerol acetate Chemical Structure

CAS No. : 2189-80-2

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生物活性

Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis[1].

IC50 & Target[1]

COX-1

116.3 μM (IC50)

COX-2

94.7 μM (IC50)

体外研究
(In Vitro)

Taraxerol acetate(10-150 µM; 24 or 48 hours) induces a dose- and time-dependent cytotoxic effects in the U87 cells, exhibits IC50 values of 34.2 and 28.4 µM, at 24 and 48 h, respectively[2].
Taraxerol acetate(10, 50 and 150 µM; 24 hours) induces cell apoptosis, the percentage of apoptotic cells increased from 7.3% in the control cells, to 16.1, 44.1 and in the 10, 50 and 150 µM taraxerol acetate-treated cells, respectively. Furthermore, taraxerol acetate treatment led to sub-G1 cell cycle arrest with a corresponding decrease in the number of S-phase cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.75

Formula

C32H52O2

CAS 号

2189-80-2

中文名称

醋酸蒲公英霜

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ubaid Ur Rehman1 A, et al. Molecular docking of taraxerol acetate as a new COX inhibitor. Journal of the Bangladesh Pharmacological Society

    [2]. Hong JF, et al. Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration.Mol Med Rep. 2016 Jun;13(6):4541-8.

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