RPR121056(Synonyms: APC)

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RPR121056 (Synonyms: APC)

RPR121056 (APC) 是通过 CYP3A4 产生的 Irinotecan (CPT-11) 的代谢产物。Irinotecan (CPT-11) 是一种抗肿瘤药，可抑制 I 型拓扑异构酶 (topoisomerase type I)，引起细胞死亡，并用于大肠癌的研究。Irinotecan 也能直接抑制 AChE。

RPR121056(Synonyms: APC)

RPR121056 Chemical Structure

CAS No. : 181467-56-1

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生物活性

RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].

IC50 & Target

Topoisomerase type I[1]; AChE[1]
分子量

618.68

Formula

C33H38N4O8
CAS 号

181467-56-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan. Anal Chem. 2018 May 15;90(10):6012-6019.

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