Abemaciclib metabolite M18(Synonyms: LSN3106729)

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Abemaciclib metabolite M18 (Synonyms: LSN3106729)

Abemaciclib metabolite M18 (LSN3106729)，Abemaciclib 的代谢物， 是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。

Abemaciclib metabolite M18(Synonyms: LSN3106729)

Abemaciclib metabolite M18 Chemical Structure

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Abemaciclib metabolite M18 的其他形式现货产品:

Abemaciclib metabolite M18 hydrochloride

生物活性

Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].

IC50 & Target[1]

CDK4

 

CDK6

 

分子量

494.54

Formula

C25H28F2N8O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non–Small Cell Lung Cancer: A Phase Ib Study.

    [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.

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