WYE-687 dihydrochloride

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WYE-687 dihydrochloride 

WYE-687 dihydrochloride 是一种 ATP 竞争性的 mTOR 抑制剂，IC50 为 7 nM。WYE-687 dihydrochloride 抑制 mTORC1 和 mTORC2 活化。WYE-687 也抑制 PI3Kα 和 PI3Kγ，IC50 分别为 81 nM 和 3.11 μM。

WYE-687 dihydrochloride

WYE-687 dihydrochloride Chemical Structure

CAS No. : 1702364-87-1

规格 价格 是否有货
2 mg ￥4200 询问价格 & 货期
5 mg ￥7200 询问价格 & 货期

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WYE-687 dihydrochloride 的其他形式现货产品:

WYE-687

生物活性

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

IC50 & Target[1][2]

mTOR

7 nM (IC50)

mTORC1

 

mTORC2

 

PI3K alpha

81 nM (IC50)

PI3K gamma

3.11 μM (IC50)

CK1 gamma1

17.8 μM (IC50)

p38 alpha

28.9 μM (IC50)

分子量

601.53

Formula

C28H34Cl2N8O3
CAS 号

1702364-87-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40.

    [2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

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