Bullatine A(Synonyms: 雪上一枝蒿甲素)

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Bullatine A (Synonyms: 雪上一枝蒿甲素)

Bullatine A 雪上一枝蒿甲素是乌头属 genus Aconitum 的二萜类生物碱,具有抗风湿,抗炎和抗伤害感受作用。 Bullatine A 是一种有效的 P2X7 拮抗剂,可抑制 ATP 诱导的细胞凋亡和 P2X 受体介导的炎症反应。Bullatine A 能缓解过敏反应。

Bullatine A(Synonyms: 雪上一枝蒿甲素)

Bullatine A Chemical Structure

CAS No. : 1354-84-3

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生物活性

Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1]. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].

分子量

343.50

Formula

C22H33NO2

CAS 号

1354-84-3

中文名称

雪上一枝蒿甲素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Li J, et al. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Res Bull. 2013 Aug;97:81-5.

    [2]. Huang Q, et al. Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models. J Neuroinflammation. 2016 Aug 30;13(1):214.

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